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Nuclear stress granules

Published:2004-01-05 Issue:1 Volume:164 Page:15-17
ISSN:1540-8140
Container-title:Journal of Cell Biology
language:en
Short-container-title:

Author:

Sandqvist Anton¹²,Sistonen Lea¹³

Affiliation:

1. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FIN-20521 Turku, Finland

2. Department of Biochemistry and Pharmacy

3. Department of Biology, Åbo Akademi University, FIN-20521 Turku, Finl

Abstract

Nuclear stress granules are subnuclear compartments that form in response to heat shock and other stress stimuli. Although many components of nuclear stress granules have been identified, including HSF1 and pre-mRNA processing factors, their function remains a mystery. A paper in this issue describes the stress-induced transcriptional activation of one of the nuclear stress granule target sites, a heterochromatic region that has been considered silent (Jolly et al., 2004). These intriguing findings will certainly give the research of these structures a new twist.

Publisher

Rockefeller University Press

Subject

Cell Biology

Link

http://rupress.org/jcb/article-pdf/164/1/15/1312192/jcb164115.pdf

Reference19 articles.

1. Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70

2. X-chromosome inactivation: counting, choice and initiation

3. Structure and dynamics of hnRNP-labelled nuclear bodies induced by stress treatments

4. X-chromosome inactivation and the search for chromosome-wide silencers

5. HSF1 granules: a novel stress-induced nuclear compartment of human cells

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