Consensus nomenclature for the human ArfGAP domain-containing proteins

Author:

Kahn Richard A.1,Bruford Elspeth2,Inoue Hiroki3,Logsdon John M.4,Nie Zhongzhen5,Premont Richard T.6,Randazzo Paul A.3,Satake Masanobu7,Theibert Anne B.8,Zapp Maria L.9,Cassel Dan10

Affiliation:

1. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322

2. HUGO Gene Nomenclature Committee, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Cambridgeshire CB10 1SA, England, UK

3. Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892

4. Department of Biology, Roy J. Carver Center for Comparative Genomics, University of Iowa, Iowa City, IA 52242

5. Department of Pathology, Medical College of Georgia, Augusta, GA 30912

6. Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC 27710

7. Department of Molecular Immunology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980-8575, Japan

8. Departments of Neurobiology and Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294

9. Program in Molecular Medicine and Center for AIDS Research, University of Massachusetts Medical School, Worcester, MA 01605

10. Department of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel

Abstract

At the FASEB summer research conference on “Arf Family GTPases”, held in Il Ciocco, Italy in June, 2007, it became evident to researchers that our understanding of the family of Arf GTPase activating proteins (ArfGAPs) has grown exponentially in recent years. A common nomenclature for these genes and proteins will facilitate discovery of biological functions and possible connections to pathogenesis. Nearly 100 researchers were contacted to generate a consensus nomenclature for human ArfGAPs. This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP domain.

Publisher

Rockefeller University Press

Subject

Cell Biology

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