Abstract
This review overlooks the current international, and national status of chronic hepatitis C. Presence of antiHCV antibodies is used as a marker for chronic hepatitis C. With the help of molecular biology techniques, seven
major HCV genotypes were identified worldwide. In addition, the latest genome sequencing techniques (SBT, NextGeneration Sequencing) analyzed the relationship between the HLA genes and KIR genes with chronic hepatitis
C. Three HLA alleles (HLA A*23:01, B*44:02, and C*04:02) and four KIR genes (KIR2DL3, KIR2DL5, KIR2DS4, and
KIR3DL3) have been associated with the chronic HCV infection in Romania and worldwide.
Publisher
Institutul National de Cercetare Dezvoltare Medico-Militara "Cantacuzino"
Reference26 articles.
1. "1. Lavanchy D. Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect. 2011;17(2):107-15. doi: 10.1111/j.1469-0691.2010.03432.x.
2. 2. Manuc D, Preda CM, Sandra I, Baicus C, Cerban R, Constantinescu I, et al. Signification of Serum Alpha-Fetoprotein Levels in Cases of Compensated Cirrhosis and Hepatitis C Virus without Hepatocellular Carcinoma. J Med Life. 2020;13(1):68- 74. doi: 10.25122/jml-2019-0076.
3. 3. Lopes H, Baptista-Leite R, Franco D, Eclemea I, Bratu EC, Furtunescu FL, et al. Modeling the Puzzle of Hepatitis C Epidemiology in Romania: A Pathway to Control. J Gastrointestin Liver Dis. 2020;29(3):377-84. doi: 10.15403/jgld-643.
4. 4. World Health Organization. Hepatitis C [Internet]. 2022 [cited 2022 Oct 29]. Available from: https://www. who.int/news-room/fact-sheets/detail/hepatitis-c
5. 5. European Centre for Disease Prevention and Control. Hepatitis C - Annual Epidemiological Report for 2021 [Internet]. 2022 [cited 2022 Sept 7]. Available from: https://www.ecdc.europa.eu/en/publicationsdata/hepatitis-c-annual-epidemiological-report-2021