Biofilm tolerance, resistance and infections increasing threat of public health
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Published:2023-11-06
Issue:11
Volume:10
Page:233-247
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ISSN:2311-2638
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Container-title:Microbial Cell
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language:
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Short-container-title:Microb Cell
Author:
Yang Shanshan,Li Xinfei,Cang Weihe,Mu Delun,Ji Shuaiqi,An Yuejia,Wu Rina,Wu Junrui
Abstract
Microbial biofilms can cause chronic infection. In the clinical setting, the biofilm-related infections usually persist and reoccur; the main reason is the increased antibiotic resistance of biofilms. Traditional antibiotic therapy is not effective and might increase the threat of antibiotic resistance to public health. Therefore, it is urgent to study the tolerance and resistance mechanism of biofilms to antibiotics and find effective therapies for biofilm-related infections. The tolerance mechanism and host reaction of biofilm to antibiotics are reviewed, and bacterial biofilm related diseases formed by human pathogens are discussed thoroughly. The review also explored the role of biofilms in the development of bacterial resistance mechanisms and proposed therapeutic intervention strategies for biofilm related diseases.
Publisher
Shared Science Publishers OG
Subject
Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Cell Biology,Genetics,Microbiology,Parasitology,Virology,Applied Microbiology and Biotechnology