Potential of photodynamic therapy in the management of infectious oral diseases

Abstract

Photodynamic therapy (PDT) can take place in the presence of three elements: Light with an appropriate wavelength; a photosensitizer; and the presence of oxygen. This type of treatment is very effective overall against bacterial, viral and mycotic cells. In the last 10 years many papers have been published on PDT with different types of photosensitizers (e.g. , methylene blue, toluidine blue, indocyanine green, curcumin-based photosensitizers), different wavelengths (e.g. , 460 nm, 630 nm, 660 nm, 810 nm) and various parameters (e.g. , power of the light, time of illumination, number of sessions). In the scientific literature all types of PDT seem very effective, even if it is difficult to find a standard protocol for each oral pathology. PDT could be an interesting way to treat some dangerous oral infections refractory to common pharmacological therapies, such as candidiasis from multidrug-resistant Candida spp .