Endothelial dysfunction as a source of short-term and long-term pathological effects in SARS-CoV-2 viral lesions

Abstract

Despite the relatively low mortality rate, SARS-CoV-2 infection is characterized by the presence of a number of complications that significantly affect the life of recovered patients. Thorough analysis of coronavirus infection mechanisms shows that endothelial dysfunction plays a key role in the development of the disease and long-term symptoms. Endothelial damage is associated with the occurrence of a number of long-term symptoms affecting various organ systems in infected patients. Also the existing polymorbidity (hypertension, obesity, diabetes mellitus, oncological and chronic respiratory diseases) in a patient with a new coronavirus infection are risk factors for a severe course of the disease development. The mutual burden of various pathologies in the potentiation of the development of new abnormalities makes it relevant to further study of endothelial dysfunction in SARS-CoV-2. The purpose of this research is to analyze current scientific data within the framework of understanding the causes of short-term and long-term pathologies associated with vascular endothelial dysfunction in SARS-CoV-2 viral lesion. Materials and methods of research: we analyze international modern scientific publications on endothelial damage in COVID-19 and its complications. Conclusion: a scientific research based on modern literature data allows to propose promising treatment strategies that can save patients from long-term complications.