Paired-Pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala

Abstract

The basolateral amygdala (BLA) has substantial effects on the neuronal transmission and synaptic plasticity processes through the dentate gyrus. Orexin neuropeptides play different roles in the sleep/wakefulness cycle, feeding, learning, and memory. The present study was conducted to investigate the function of the orexin receptors of the BLA in the hippocampal local interneuron circuits. For this, paired-pulse responses from dentate gyrus (DG) region were recorded. Within the procedure, SB-334867-A (12μg/0.5μl), and, TCS-OX2-29 (10μg/0.5μl (orexin 1 and 2 receptors antagonists, respectively), were administered into the both side of the BLA areas of the rat brain. Dimethyl sulfoxide (DMSO) was used as the solvent in the control animals with the volume of 0.5μl. Our data indicated that the paired-pulse (PP) responses were not affected by the inactivation of the orexin receptors of the BLA.