Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy
Author:
Publisher
Korean Society for Molecular and Cellular Biology
Subject
Cell Biology,Molecular Biology,General Medicine
Link
http://ocean.kisti.re.kr/downfile/crosscheck/ksmcb/JAKO201527358961782.pdf
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1. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
2. The DNA translocase activity of FANCM protects stalled replication forks
3. Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia
4. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
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