Metformin in combination with chemotherapy increases apoptosis in gastric cancer cells and counteracts senescence induced by chemotherapy

Author:

Vázquez‑Ibarra Katia1,Sánchez López Josefina2,Pineda Razo Tomás3,Cruz Lozano José4,Ortiz‑Tamayo Brenda5,Palafox‑Mariscal Luis4,González Arreola Rosa1,González‑García Juan2,Ortiz-Lazareno Pablo6

Affiliation:

1. Department of Molecular Biology and Genomics, University Center for Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico

2. Genetic Division, Western Biomedical Research Center, Mexican Social Security Institute, Guadalajara, Jalisco, 44340, Mexico

3. Medical Oncology Service, Western National Medical Center, Mexican Social Security Institute, Guadalajara, Jalisco 44329, Mexico

4. Department of Physiology, University Center for Health Sciences, University of Guadalajara, Guadalajara, Jalisco 44340, Mexico

5. Division of Biological and Environmental Sciences, University Center of Biological and Agricultural Sciences, University of Guadalajara, Guadalajara, Jalisco 44600, Mexico

6. Immunology Division, Western Biomedical Research Center, Mexican Social Security Institute, Guadalajara, Jalisco 44340, Mexico

Publisher

Spandidos Publications

Reference58 articles.

1. Cancer statistics for the year 2020: An overview;Ferlay;Int J Cancer,2021

2. Changing trends in stomach cancer throughout the world;Balakrishnan;Curr Gastroenterol Rep,2017

3. Gastric cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up;Smyth;Ann Oncol,2016

4. Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review;Chiurillo;World J Exp Med,2015

5. Epidemiology of gastric cancer: Global trends, risk factors and prevention;Rawla;Prz Gastroenterol,2019

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