Checkpoint kinase‑1 inhibition and etoposide exhibit a strong synergistic anticancer effect on chronic myeloid leukemia cell line K562 by impairing homologous recombination DNA damage repair

Author:

Fan Zhuoyi1,Luo Huacheng2,Zhou Jie1,Wang Fangce1,Zhang Wenjun1,Wang Jian3,Li Shuo4,Lai Qian5,Xu Yueshuang6,Wang Guangming1,Liang Aibin1,Xu Jun3

Affiliation:

1. Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R.�China

2. Division of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA

3. East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R.�China

4. Jake Gittlen Laboratories for Cancer Research, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA

5. Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, School of Medicine, Xiamen University, Xiamen, Fujian 361003, P.R. China

6. Department of Pathology, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, P.R. China

Publisher

Spandidos Publications

Subject

Cancer Research,Oncology,General Medicine

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