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Ophiopogonin B induces gastric cancer cell death by blocking the GPX4/xCT‑dependent ferroptosis pathway

  • Published:2022-02-01 Issue:3 Volume:23 Page:
  • ISSN:1792-1074
  • Container-title:Oncology Letters
  • language:
  • Short-container-title:Oncol Lett

Author:

Zhang Liyi1,Li Chunlei1,Zhang Yuzhan2,Zhang Jinwen3,Yang Xiaolei4

Affiliation:

1. Department of Internal Medicine, Jiaozhou Central Hospital, Qingdao, Shandong 266300, P.R. China

2. Department of Cardiothoracic Surgery, Shanxian Dongda Hospital, Heze, Shandong 274300, P.R. China

3. Department of Laboratory Medicine, Heze Hospital of Traditional Chinese Medicine, Heze, Shandong 274000, P.R. China

4. Department of General Surgery, 80th Army Hospital, Weifang, Shandong 261021, P.R. China

Publisher

Spandidos Publications

Subject

Cancer Research,Oncology

Reference28 articles.

1. Fibulin-2 inhibits development of gastric cancer by downregulating β-catenin;Ma;Oncol Lett,2019

2. Regulation of lncRNA PVT1 on miR-125 in metastasis of gastric cancer cells;Niu;Oncol Lett,2020

3. High expression of fibronectin 1 indicates poor prognosis in gastric cancer;Sun;Oncol Lett,2020

4. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis;Bersuker;Nature,2019

5. Lipid peroxidation and GPX4 inhibition are common causes for myofibroblast differentiation and ferroptosis;Gong;DNA Cell Biol,2019

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