1. Biophysics Institute, Center for Neuroscience and Cell Biology and Institute for Biomedical Imaging and Life Sciences (CNC.IBILI), Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal
2. Faculty of Medical Sciences of University of Campinas (FCM/UNICAMP), Campinas, SP 13083‑887, Brazil
3. Department of Gastroenterology, Hospital de Santo Andr�, 2410-197 Leiria, Portugal
4. Laboratory of Biostatistics and Medical Informatics, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal
5. Department of Surgery, Faculty of Medical Sciences of University of Campinas (FCM/UNICAMP), Campinas, SP 13083‑887, Brazil
6. Institute for Clinical and Biomedical Research Area of Environment Genetics and Oncobiology, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal
7. Laboratory of Oncobiology and Hematology, Applied Molecular Biology and University Clinic of Hematology, Faculty of Medicine, University of Coimbra, 3000‑354 Coimbra, Portugal
8. Surgery Department A, Coimbra Hospital and University Centre, 3004‑531 Coimbra, Portugal
9. Department of Molecular Biology, Faculty of Medicine of S�o Jos� do Rio Preto (FAMERP), S�o Jos� do Rio Preto, SP 15090‑000, Brazil