Abstract
Marine Natural Products (MNPs) isolated from samples collected in Colombia have been an object of study since the early 1980's; however, this information is neither integrated nor compiled. This systematic review describes the articles published in scientific journals up to December 2019. 173 papers met the inclusion criteria of focusing on MNPs obtained from specimens collected from Colombian seas; all original papers written in English, Portuguese or Spanish. The selected papers were mostly authored by researchers from Colombian groups, with low interaction amongst themselves. 99.4% of the papers studied samples collected from the Caribbean Sea; 183 species were studied, mainly sponges and octocorals. In this study, 1,690 compounds (238 new ones) were reviewed, mainly diterpenes and sterol derivatives. Of the selected papers, 76.8% measured various biological activities, including antibiotic (34%) and anticancer (30%). These papers were published in 51 journals (74.6% were international). In conclusion, scientific work on natural marine products of Colombian origin has incremented over time. The most relevant opportunities to address and fill existing gaps comprise: exploring Pacific Ocean organisms and several of the misrepresented taxa; promoting strong interactions amongst the MNPs research groups, and accordingly with other areas of knowledge; and having the productive sector participate in MNPs research.
Publisher
Universidad Nacional de Colombia
Reference30 articles.
1. M. Costa, J. Puga, J. Serõdio, N. Gomes, y R. Calado, «Trends in the discovery of new marine natural products from invertebrates over the last two decades – where and what are we bioprospecting?», New Mar. Nat. Prod. Invertebr., vol. 7, n.o 1, pp. 1-15, 2012, doi: 10.1371/journal.pone.0030580.
2. Y. Hu et al., «Statistical research on the bioactivity of new marine natural products discovered during the 28 years from 1985 to 2012», Mar. Drugs, vol. 13, pp. 202-221, 2015, doi: 10.3390/md13010202.
3. B. Haefner, «Drugs from the deep: Marine natural products as drug candidates», Drug Discov. Today, vol. 8, n.o 12, pp. 536-544, 2003, doi: 10.1016/S1359-6446(03)02713-2.
4. H. M. Le, D. J. Newman, K. B. Glaser, y A. M. Mayer, «The Marine Pharmacology and Pharmaceuticals Pipeline in 2020», Faseb J., n.o 16 April 2020, 2020.
5. D.-X. Kong, Y.-Y. Jiang, y H.-Y. Zhang, «Marine natural products as sources of novel scaffolds: Achievement and concern», Drug Discov. Today, vol. 15, n.o 21-22, pp. 884-886, 2010, doi: 10.1016/j.drudis.2010.09.002.
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献