Author:
Gómez Rave Lyz Jenny,Muñoz Bravo Adriana Ximena,Sierra Castrillo Jhoalmis,Román Marín Laura Melisa,Corredor Pereira Carlos
Abstract
Cancer is a public health problem due to its high worldwide morbimortality. Current treatment protocols do not guarantee complete remission, which has prompted to search for new and more effective antitumoral compounds. Several substances exhibiting cytostatic and cytotoxic effects over cancer cells might contribute to the treatment of this pathology. Some studies indicate the presence of such substances in scorpion venom. In this review, we report characteristics of the principal scorpion venom components found in recent literature and their potential activity against tumor cells. There are different toxin groups present in the venom, and it seems that their mode of actions involves ionic channel blocking, disruption of the cell membrane integrity and damage to internal cell organelles. These properties make good prospects for studies on drugs and adjuvants in cancer treatment.
Publisher
Universidad Nacional de Colombia
Subject
General Agricultural and Biological Sciences
Cited by
11 articles.
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