A Randomized Two Stage Adaptively Censored Design With Application to Testing-Reference-Cited by-同舟云学术

A Randomized Two Stage Adaptively Censored Design With Application to Testing

Published:2019-07-01 Issue:2 Volume:42 Page:209-224
ISSN:2389-8976
Container-title:Revista Colombiana de Estadística
language:
Short-container-title:Rev. colomb. estad.

Author:

Bandyopadhyay Uttam,Bhattacharya Rahul

Abstract

A two stage randomized design is developed for two treatment clinical trials in which response variables are exponential and the observations are censored by using failure censoring and time censoring in the first and second stages respectively. The censoring time for the second stage is determined from the outcomes of the first stage. An application to testing for the equality of treatment effects is given along with a comparative study with relevant properties.

Publisher

Universidad Nacional de Colombia

Subject

Statistics and Probability

Reference11 articles.

1. Bandyopadhyay, U. & Bhattacharya, R. (2001), ‘Estimation in a two stage procedure for failure censored model’, Calcutta Statistical Association Bulletin 51, 179–190.

2. Bandyopadhyay, U., Biswas, A. & Bhattacharya, R. (2009), ‘A bayesian adap tive design for two-stage clinical trials with survival data’, Life Time Data Analysis 15, 468–492.

3. Bhattacharya, B. (2007), ‘Testing for ordered failure rates under general progressive censoring’, Journal of Statistical Planning and Inference 137, 1775–1786.

4. Biswas, A., Bhattacharya, R. & Park, E. (2016), ‘On a class of optimal covariate adjusted response adaptive designs for survival outcomes’, Statistical Methods in Medical Research 25, 2444–2456.

5. Coad, D. S. (1992), ‘Some results on estimation for two stage clinical trials’, Sequential Analysis 11, 299–311.