Abstract
Background. Acceleration of fracture healing is a phenomenon known for over 30 years and is observed in patients with concomitant cranio-skeletal trauma. To date, there is no single theory explaining the phenomenon. The search for factors that determine this phenomenon is ongoing. The purpose of the study was to assess changes in serum indicators as potential predictors of the phenomenon of accelerated osteogenesis in the experiment. Materials and methods. Experimental animals, female white rats (n = 90), were randomly divided into two groups: control (n = 45) with isolated femoral fracture and experimental (n = 45) with cranio-skeletal polytrauma. The dynamics of serum indices were determined on days 7, 14, and 21. Results. The average lactate dehydrogenase activity decreased (p < 0.001) in both groups on day 14 to equal values (p = 0.88). In the experimental group, lactate dehydrogenase activity remained lower (by 23 %, p = 0.004), while in control group it increased (by 30 %, p = 0.015). The alkaline phosphatase activity in the control group increased both on day 14 (by 105 %, p < 0.001) and on day 21 (by 19 %, p = 0.06). The protein level decreased by 14 % (p < 0.001) compared to day 7 only in polytrauma group, while in control group data were not evident enough (p>0.05). The average blood calcium in polytrauma group decreased (by 48 %, p < 0.001) on day 14 compared to day 7 but increased to baseline values on day 21 (p < 0.001). In control group, a decrease in calcium levels was observed both day 14 (p = 0.007) and day 21 (p = 0.001). Conclusions. On day 14 calcium concentration decreased in both isolated trauma (by 15 %, p < 0.001) and polytrauma (by 48 %, p < 0.001) groups. While lactate dehydrogenase activity decreased in both groups on day 14, alkaline phosphatase activity increased to its peak value. The blood protein should not be considered a relevant marker of fracture healing acceleration
Publisher
Publishing House Zaslavsky