Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB-Reference-Cited by-同舟云学术

Shikonin Isolated from Lithospermum erythrorhizon Downregulates Proinflammatory Mediators in Lipopolysaccharide-Stimulated BV2 Microglial Cells by Suppressing Crosstalk between Reactive Oxygen Species and NF-κB

Published:2015-03-31 Issue:2 Volume:23 Page:110-118
ISSN:2005-4483
Container-title:Biomolecules & Therapeutics
language:en
Short-container-title:Biomolecules & Therapeutics

Author:

Prasad Rajapaksha Gedara¹,Choi Yung Hyun²,Kim Gi-Young¹

Affiliation:

1. Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea

2. Department of Biochemistry, College of Oriental Medicine, Dongeui University, Busan 614-051, Republic of Korea

Funder

Jeju National University(Cheju National University)

Publisher

The Korean Society of Applied Pharmacology

Subject

Drug Discovery,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pdf.medrang.co.kr/BT2/2015/023/bt-23-110.pdf

Reference38 articles.

1. Shikonin promotes intestinal wound healing in vitro via induction of TGF-β release in IEC-18 cells

2. Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

3. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

4. Reactive Oxygen Intermediate-Dependent NF-κB Activation by Interleukin-1β Requires 5-Lipoxygenase or NADPH Oxidase Activity

5. NF-κB as a therapeutic target in neurodegenerative diseases

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Enzymatic and ultrasound assisted β-cyclodextrin extraction of active ingredients from Forsythia suspensa and their antioxidant and anti-inflammatory activities;Ultrasonics Sonochemistry;2024-08

2. Chemical constituents from Notopterygium incisum and their anti-neuroinflammatory activity;Fitoterapia;2024-07

3. Shikonin attenuates cerebral ischemia/reperfusion injury via inhibiting NOD2/RIP2/NF-κB-mediated microglia polarization and neuroinflammation;Journal of Stroke and Cerebrovascular Diseases;2024-06

4. Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia;Brain Sciences;2024-03-28

5. Sodium alginate/polyvinyl alcohol nanofibers loaded with Shikonin for diabetic wound healing: In vivo and in vitro evaluation;International Journal of Biological Macromolecules;2024-03