Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases-Reference-Cited by-同舟云学术

Development of a Label-Free LC-MS/MS-Based Glucosylceramide Synthase Assay and Its Application to Inhibitors Screening for Ceramide-Related Diseases

Published:2019-03-01 Issue:2 Volume:27 Page:193-200
ISSN:1976-9148
Container-title:Biomolecules & Therapeutics
language:en
Short-container-title:Biomol Ther

Author:

Fu Zhicheng¹,Yun So Yoon¹,Won Jong Hoon¹,Back Moon Jung¹,Jang Ji Min¹,Ha Hae Chan¹,Lee Hae Kyung¹,Shin In Chul¹,Kim Ju Yeun¹,Kim Hee Soo¹,Kim Dae Kyong¹

Affiliation:

1. Department of Environmental & Health Chemistry, College of Pharmacy, Chung-Ang University, Seoul 06974, Republic of Korea

Funder

Chung-Ang University

Publisher

The Korean Society of Applied Pharmacology

Subject

Drug Discovery,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pdf.medrang.co.kr/BT2/2019/027/BT027-02-09.pdf

Reference39 articles.

1. Improved Inhibitors of Glucosylceramide Synthase1

2. Abe, A, Radin, NS, Shayman, JA, Wotring, LL, Zipkin, RE, Sivakumar, R, Ruggieri, JM, Carson, KG, and Ganem, B (1995). Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth. J. Lipid Res. 36, 611-621.

3. Basu, S, Kaufman, B, and Roseman, S (1973). Enzymatic synthesis of glucocerebroside by a glucosyltransferase from embryonic chicken brain. J. Biol. Chem. 248, 1388-1394.

4. Gaucher Disease and Its Treatment Options

5. Glucosylceramide synthase and apoptosis

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