Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner-Reference-Cited by-同舟云学术

Fasiglifam (TAK-875), a G Protein-Coupled Receptor 40 (GPR40) Agonist, May Induce Hepatotoxicity through Reactive Oxygen Species Generation in a GPR40-Dependent Manner

Published:2018-11-01 Issue:6 Volume:26 Page:599-607
ISSN:1976-9148
Container-title:Biomolecules & Therapeutics
language:en
Short-container-title:Biomolecules & Therapeutics

Author:

Kim MinJeong¹,Gu Gyo Jeong²,Koh Yun-Sook¹,Lee Su-Hyun³,Na Yi Rang²,Seok Seung Hyeok²,Lim Kyung-Min¹

Affiliation:

1. College of Pharmacology, Ewha Womans University, Seoul 03760, Republic of Korea

2. Department of Microbiology and Immunology and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

3. Biosolutions Co., Seoul 01811, Republic of Korea

Funder

National Research Foundation of Korea(NRF)

Publisher

The Korean Society of Applied Pharmacology

Subject

Drug Discovery,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pdf.medrang.co.kr/BT2/2018/026/BT026-06-11.pdf

Reference47 articles.

1. Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS 64)

2. GPR41 Gene Expression Is Mediated by Internal Ribosome Entry Site (IRES)-dependent Translation of Bicistronic mRNA Encoding GPR40 and GPR41 Proteins