Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
Author:
Affiliation:
1. Department of Cell Biology and Histology, University of the Basque Country, School of Medicine and Nursing, Leioa 48940, Bizkaia, Spain
Funder
Department of Industry and Research of the Basque Government SAIOTEK
Ministerio de Ciencia y Tecnología
Publisher
The Korean Society of Applied Pharmacology
Subject
Drug Discovery,Pharmacology,Molecular Medicine,Biochemistry
Link
http://pdf.medrang.co.kr/BT2/2021/029/BT2029-03-342.pdf
Reference44 articles.
1. Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice
2. Decreased expression of the β2 integrin on tumor cells is associated with a reduction in liver metastasis of colorectal cancer in mice
3. CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver
4. Liver sinusoidal endothelial cell ICAM-1 mediated tumor/endothelial crosstalk drives the development of liver metastasis by initiating inflammatory and angiogenic responses
5. Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion
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