Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21<sup>waf1/cip1</sup> expression-Reference-Cited by-同舟云学术

Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21^waf1/cip1 expression

Published:2016 Issue:2 Volume:58 Page:105-113
ISSN:0912-0009
Container-title:Journal of Clinical Biochemistry and Nutrition
language:en
Short-container-title:J. Clin. Biochem. Nutr.

Author:

Fei Zhewei¹,Gao Yong²,Qiu Mingke³,Qi Xianqin³,Dai Yuxin³,Wang Shuqing³,Quan Zhiwei³,Liu Yingbin³,Ou Jingmin³

Affiliation:

1. Department of General Surgery, Xinhua Hospital (Chong Ming) affiliated to Shanghai Jiaotong University School of Medicine

2. Department of Vascular Surgery, The First Affiliated Hospital of Bengbu Medical College

3. Department of General Surgery, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine

Publisher

The Society for Free Radical Research Japan

Subject

Clinical Biochemistry,Nutrition and Dietetics,Medicine (miscellaneous)

Link

https://www.jstage.jst.go.jp/article/jcbn/58/2/58_15-64/_pdf

Reference48 articles.

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2. 2 Bailey SW, Ayling JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci U S A 2009; 106: 15424–15429.

3. 3 Sun DF, Weng YR, Chen YX, Lu R, Wang X, Fang JY. Knock-down of methylenetetrahydrofolate reductase reduces gastric cancer cell survival: an in vitro study. Cell Biol Int 2008; 32: 879–887.

4. 4 Yi X, Zhou Y, Jiang D, Li X, Guo Y, Jiang X. Efficacy of folic acid supplementation on endothelial function and plasma homocysteine concentration in coronary artery disease: a meta-analysis of randomized controlled trials. Exp Ther Med 2014; 7: 1100–1110.

5. 5 Baszczuk A, Kopczyński Z. Hyperhomocysteinemia in patients with cardiovascular disease. Postepy Hig Med Dosw (Online) 2014; 68: 579–589(in Polish).

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