D-Cysteine supplementation partially protects against ferroptosis induced by xCT dysfunction via increasing the availability of glutathione
Author:
Affiliation:
1. Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University
2. Department of Medical Technology, Faculty of Medicine, Niigata University
Publisher
The Society for Free Radical Research Japan
Subject
Clinical Biochemistry,Nutrition and Dietetics,Medicine (miscellaneous)
Link
https://www.jstage.jst.go.jp/article/jcbn/71/1/71_21-143/_pdf
Reference23 articles.
1. 1 Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 2012; 149: 1060–1072.
2. 2 Stockwell BR, Friedmann Angeli JP, Bayir H, et al. Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 2017; 171: 273–285.
3. 3 Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 2014; 156: 317–331.
4. 4 Fujii J, Homma T, Kobayashi S. Ferroptosis caused by cysteine insufficiency and oxidative insult. Free Radic Res 2020; 54: 969–980.
5. 5 Freidman N, Chen I, Wu Q, et al. Amino acid transporters and exchangers from the SLC1A family: structure, mechanism and roles in physiology and cancer. Neurochem Res 2020; 45: 1268–1286.
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