From Genetics to Precision Therapy: Finding a Path through the Scientific Valley of Death
Author:
Affiliation:
1. Rainbow Babies and Children’s HospitalCase Western Reserve UniversityCleveland, Ohioand
2. Riley Hospital for ChildrenIndianapolis, Indiana
Publisher
American Thoracic Society
Subject
Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology
Link
https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2019-0216ED
Reference15 articles.
1. Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis
2. New Therapeutic Approaches to Modulate and Correct Cystic Fibrosis Transmembrane Conductance Regulator
3. Valley of death: A proposal to build a “translational bridge” for the next generation
4. Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis
5. 1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo
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