The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke

Author:

Raju S. Vamsee,Lin Vivian Y.,Liu Limbo,McNicholas Carmel M.,Karki Suman,Sloane Peter A.,Tang Liping,Jackson Patricia L.,Wang Wei,Wilson Landon,Macon Kevin J.,Mazur Marina,Kappes John C.,DeLucas Lawrence J.,Barnes Stephen,Kirk Kevin,Tearney Guillermo J.,Rowe Steven M.

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

Reference37 articles.

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2. National Heart, Lung, and Blood Institute. COPD: the more you know, the better for you and your loved ones. Sep 2013 [accessed 2014 Jun 10]. Available from: https://www.nhlbi.nih.gov/health/educational/copd/campaign-materials/pub/copd-atrisk.pdf

3. Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

4. Inhibition of chloride secretion in human bronchial epithelial cells by cigarette smoke extract

5. Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells

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