A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples

Author:

Madan Taruna1ORCID,Biswas Barnali1,Varghese Praveen M.23ORCID,Subedi Rambhadur1,Pandit Hrishikesh1,Idicula-Thomas Susan4,Kundu Indra4,Rooge Sheetalnath5,Agarwal Reshu5,Tripathi Dinesh M.6,Kaur Savneet6,Gupta Ekta5,Gupta Sanjeev K.7,Kishore Uday2

Affiliation:

1. Department of Innate Immunity, and

2. Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom;

3. School of Biosciences and Technology, Vellore Institute of Technology, Vellore, India;

4. Biomedical Informatics Centre, ICMR-National Institute for Research in Reproductive Health, Mumbai, India;

5. Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, Delhi, India;

6. Department of Virology, Institute of Liver and Biliary Sciences, Delhi, India; and

7. Intrust Consulting, Mumbai, India

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

Reference38 articles.

1. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

2. A Novel Coronavirus from Patients with Pneumonia in China, 2019

3. World Health Organization. COVID-19 weekly epidemiological update - 24 November 2020, Geneva, Switzerland: World Health Organization; 2020. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update-24-november-2020.

4. Targeting TMPRSS2 in SARS-CoV-2 Infection

5. National Institutes of Health. Therapeutic management of adults with COVID-19. Bethesda, MD: National Institutes of Health; 2021 [accessed 2021 Feb 2]. Available from: https://www.covid19treatmentguidelines.nih.gov/therapeutic-management/.

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