Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2-Reference-Cited by-同舟云学术

Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2

Published:2023-05 Issue:5 Volume:68 Page:566-576
ISSN:1044-1549
Container-title:American Journal of Respiratory Cell and Molecular Biology
language:en
Short-container-title:Am J Respir Cell Mol Biol

Author:

Bednash Joseph S.¹^ORCID,Johns Finny¹,Farkas Daniela¹,Elhance Ajit¹,Adair Jessica¹,Cress Kirstin¹,Yount Jacob S.²^ORCID,Kenney Adam D.²,Londino James D.¹,Mallampalli Rama K.¹^ORCID

Affiliation:

1. Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, and

2. Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio

Funder

National Institute of Allergy and Infectious Diseases

National Heart, Lung, and Blood Institute

National Center for Advancing Translational Sciences

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

Link

https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2022-0331OC

Reference45 articles.

1. A Novel Coronavirus from Patients with Pneumonia in China, 2019

2. Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

3. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

4. Cell entry mechanisms of SARS-CoV-2

5. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

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1. Inhibition of the Cellular Deubiquitinase UCHL1 Suppresses SARS-CoV-2 Replication;American Journal of Respiratory Cell and Molecular Biology;2023-09

2. ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification;Journal of Biomedical Science;2023-08-22

3. Role of E3 ubiquitin ligases and deubiquitinating enzymes in SARS-CoV-2 infection;Frontiers in Cellular and Infection Microbiology;2023-06-09

4. Tipping the Balance of Ubiquitination toward a Therapy for COVID-19;American Journal of Respiratory Cell and Molecular Biology;2023-05