Endogenous and Therapeutic 25-Hydroxycholesterols May Worsen Early SARS-CoV-2 Pathogenesis in Mice

Author:

Fessler Michael B.1,Madenspacher Jennifer H.1,Baker Paul J.2,Hilligan Kerry L.3,Bohrer Andrea C.2,Castro Ehydel2,Meacham Julie1,Chen Shih-Heng4,Johnson Reed F.5,McDonald Jeffrey G.67,Martin Negin P.4,Tucker Charles J.8,Mahapatra Debabrata9,Cesta Mark10,Mayer-Barber Katrin D.2

Affiliation:

1. Immunity, Inflammation and Disease Laboratory,

2. Inflammation and Innate Immunity Unit,

3. Immunobiology Section, and

4. Viral Vector Core Facility, Neurobiology Laboratory,

5. SARS-CoV-2 Virology Core, Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;

6. Department of Molecular Genetics and

7. Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas; and

8. Fluorescence Microscopy and Imaging Center, Signal Transduction Laboratory, and

9. Integrated Laboratory Systems, LLC, Research Triangle Park, North Carolina

10. Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina;

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

National Institute of Environmental Health Sciences

CTSA

National Institute of Diabetes and Digestive and Kidney Diseases

National Heart, Lung, and Blood Institute

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

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