Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis

Author:

Santos-Ribeiro Diana1ORCID,Lecocq Marylène1,de Beukelaer Michèle2,Verleden Stijn3,Bouzin Caroline2,Ambroise Jérôme4,Dorfmuller Peter5,Yakoub Yousef6,Huaux François6,Quarck Rozenn7ORCID,Karmouty-Quintana Harry8910ORCID,Ghigna Maria-Rosa111213,Bignard Juliette14,Nadaud Sophie14,Soubrier Florent14,Horman Sandrine15,Perros Frederic11131617,Godinas Laurent7,Pilette Charles118

Affiliation:

1. Pneumology, ENT and Dermatology,

2. Imaging Platform (2IP),

3. Laboratory of Respiratory Diseases & Thoracic Surgery, Department of Chronic Diseases and Metabolism, and

4. Applied Molecular Technologies Center,

5. Department of Pathology, University of Giessen and Marburg Lung Center, Justus-Liebig University Giessen, German Center for Lung Research, Giessen, Germany;

6. Louvain Center for Toxicology and Applied Pharmacology, and

7. Clinical Department of Respiratory Diseases, University Hospitals – University of Leuven, Leuven, Belgium;

8. Department of Biochemistry and Molecular Biology and

9. Division of Critical Care and

10. Division of Pulmonary and Sleep Medicine, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas;

11. Faculté de Médecine, Université Paris-Saclay, Le Kremlin-Bicêtre, France;

12. Département de Pathologie and

13. INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis-Robinson, France;

14. UMR_S 1166-ICAN, INSERM, Sorbonne Université, Paris, France;

15. Cardiovascular Research Unit, Institute of Experimental and Clinical Research, Catholic University of Louvain, Brussels, Belgium;

16. Assistance Publique–Hôpitaux de Paris, Centre de Référence de l’Hypertension Pulmonaire, Service de Pneumologie et Soins Intensifs Respiratoires, Hôpital Bicêtre, Le Kremlin-Bicêtre, France;

17. Laboratoire CarMeN, UMR INSERM U1060/INRA U1397, Université Claude Bernard Lyon1, Pierre-Bénite and Bron, France; and

18. Département de Pneumologie, Cliniques Universitaires St-Luc, Brussels, Belgium

Funder

Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture

Fondation Louvain

Fondation Mont-Godinne

Fonds National de la Recherche Scientifique

Publisher

American Thoracic Society

Subject

Cell Biology,Clinical Biochemistry,Pulmonary and Respiratory Medicine,Molecular Biology

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