Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction

Author:

Ribeuz Hélène Le12ORCID,Willer Anaïs Saint-Martin12ORCID,Chevalier Benoit3,Sancho Maria456,Masson Bastien12ORCID,Eyries Mélanie7ORCID,Jung Vincent8ORCID,Guerrera Ida Chiara8ORCID,Dutheil Mary12,Jekmek Kristelle El12,Laubry Loann12ORCID,Carpentier Gilles9,Perez-Vizcaino Francisco10611ORCID,Tu Ly12ORCID,Guignabert Christophe12ORCID,Chaumais Marie-Camille21213ORCID,Péchoux Christine14,Humbert Marc1213ORCID,Hinzpeter Alexandre3,Mercier Olaf1215ORCID,Capuano Véronique12,Montani David1213ORCID,Antigny Fabrice12ORCID

Affiliation:

1. Paris-Saclay University, Faculty of Medecine, Le Kremlin-Bicêtre, France;

2. INSERM UMR_S 999 Pulmonary Hypertension: Pathophysiology and Novel Therapies, Marie Lannelongue Hospital, Le Plessis-Robinson, France;

3. Paris Cité University, CNRS, INSERM, Institut Necker Enfants Malades-INEM, Paris, France;

4. Department of Physiology and

5. Department of Pharmacology, University of Vermont, Burlington, Vermont;

6. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain;

7. Genetics Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France;

8. INSERM US24/CNRS UAR3633, Proteomic Platform Necker, Université Paris Cité-Federative Research Structure Necker, Paris, France;

9. Gly-CRRET Research Unit 4397, Paris-Est Créteil University, Créteil, France;

10. Department of Pharmacology and Toxicology, Faculty of Medicine, University Complutense of Madrid, Madrid, Spain;

11. Ciber Enfermedades Respiratorias (CIBERES), Madrid, Spain;

12. Paris-Saclay University, Faculty of Pharmacy, Orsay, France;

13. Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Bicêtre Hospital, Le Kremlin-Bicêtre, France;

14. Paris-Saclay University, INRAE, AgroparisTech, GABI, Jouy-en-Josas, France;

15. Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Groupe Hospitalier Paris Saint-Joseph-Marie Lannelongue Hospital, Le Plessis-Robinson, France.

Funder

Agence Nationale de la Recherche

Publisher

American Thoracic Society

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