Photodynamic Therapy Using a Novel Phosphorus Tetraphenylporphyrin Induces an Anticancer Effect via Bax/Bcl-xL-related Mitochondrial Apoptosis in Biliary Cancer Cells

Author:

Mai Nguyen Nhat Huynh12,Yamaguchi Yuya13,Choijookhuu Narantsog1,Matsumoto Jin4,Nanashima Atsushi5,Takagi Hideaki6,Sato Katsuaki6,Tuan Le Quoc2,Hishikawa Yoshitaka1

Affiliation:

1. Department of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki

2. Faculty of Environment and Natural Resources, Nong Lam University

3. Present address: Division of Cellular Physiology, Department of Physiology, Faculty of Medicine, Toho University

4. Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki

5. Department of Surgery, Faculty of Medicine, University of Miyazaki

6. Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference49 articles.

1. 1 Agostinis, P., Berg, K., Cengel, K. A., Foster, T. H., Girotti, A. W., Gollnick, S. O., et al. (2011) Photodynamic therapy of cancer: an update. CA Cancer J. Clin. 61; 250–281.

2. 2 Ali, M. N., Choijookhuu, N., Takagi, H., Srisowanna, N., Nguyen Nhat Huynh, M., Yamaguchi, Y., et al. (2018) The HDAC inhibitor, SAHA, prevents colonic inflammation by suppressing pro-inflammatory cytokines and chemokines in DSS-induced colitis. Acta Histochem. Cytochem. 51; 33–40.

3. 3 An, S., Hishikawa, Y., Liu, J. and Koji, T. J. A. (2007) Lung injury after ischemia-reperfusion of small intestine in rats involves apoptosis of type II alveolar epithelial cells mediated by TNF-α and activation of Bid pathway. Apoptosis 12; 1989–2001.

4. 4 Aranha, O., Grignon, R., Fernandes, N., McDonnell, T. J., Wood, D. P. and Sarkar, F. H. (2003) Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis. Int. J. Oncol. 22; 787–794.

5. 5 Baskaran, R., Lee, J. and Yang, S. G. (2018) Clinical develop­ment of photodynamic agents and therapeutic applications. Biomater. Res. 22; 25.

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