Stimulation of Osteogenesis in Bone Defects Implanted with Biodegradable Hydroxyapatite Composed of Rod-Shaped Particles under Mechanical Unloading

Author:

Ikeda Tohru11,Gonda Yoshinori12312,Tatsukawa Eri11,Shibata Yasuaki11,Kamitakahara Masanobu44,Okuda Takatoshi22,Yonezawa Ikuho22,Kurosawa Hisashi2525,Ioku Koji44

Affiliation:

1. Department of Oral Pathology and Bone Metabolism, Basic Medical Sciences Unit, Nagasaki University Graduate School of Biomedical Sciences

2. Department of Orthopedic Surgery, School of Medicine, Juntendo University

3. Present address: Department of Orthopedic Surgery, Juntendo University Urayasu Hospital

4. Graduate School of Environmental Studies, Tohoku University

5. Present address: Department of Orthopedic Surgery, Juntendo Tokyo Koto Geriatric Medical Center

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference40 articles.

1. 1. Anker, C. J., Holdridge, S. P., Baird, B., Cohen, H. and Damron, T. A. (2005) Ultraporous beta-tricalcium phosphate is well incorporated in small cavitary defects. Clin. Orthop. Relat. Res. 434; 251-257.

2. 4. Bikle, D. D., Morey-Holton, E. R., Doty, S. B., Currier, P. A., Tanner, S. J. and Halloran, B. P. (1994) Alendronate increases skeletal mass of growing rats during unloading by inhibiting resorption of calcified cartilage. J. Bone Miner. Res. 9; 1777-1787.

3. Osteoclast differentiation and activation

4. 6. Bucholz, R. W., Carlton, A. and Holmes, R. (1989) Interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures. Clin. Orthop. Relat. Res. 240; 53-62.

5. 7. Carmeliet, G., Vico, L. and Bouillon, R. (2001) Space flight: a challenge for normal bone homeostasis. Crit. Rev. Eukaryot. Gene Expr. 11; 131-144.

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