ACAT1-associated Late Endosomes/Lysosomes Significantly Improve Impaired Intracellular Cholesterol Metabolism and the Survival of Niemann-Pick Type C Mice

Author:

Kamikawa Masashi12,Lei XiaoFeng3,Fujiwara Yukio1,Nishitsuji Kazuchika4,Mizuta Hiroshi2,Takeya Motohiro1,Sakashita Naomi14

Affiliation:

1. Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University

2. Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kumamoto University

3. Department of Biochemistry, Showa University School of Medicine

4. Department of Human Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference29 articles.

1. 1 Buhman, K. F., Accad, M. and Ferese, R. V. (2000) Mammalian acyl-CoA:cholesterol acyltransferases. Biochim. Biophys. Acta 1529; 142–154.

2. 2 Buono, C., Li, Y., Waldo, S. W. and Kruth, H. S. (2007) Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL. J. Lipid Res. 48; 2411–2418.

3. 3 Cadigan, K. M., Spillane, D. M. and Chang, T. Y. (1990) Isolation and characterization of Chinese hamster ovary cell mutants defective in intracellular low density lipoprotein-cholesterol trafficking. J. Cell Biol. 110; 295–308.

4. 4 Chang, C. C., Chen, J., Thomas, M. A., Cheng, D., Del Priore, V. A., Newton, R. S., Pape, M. E. and Chang, T. Y. (1995) Regulation and immunolocalization of acyl-coenzyme A:cholesterol acyltransferase in mammalian cells as studied with specific antibodies. J. Biol. Chem. 270; 29532–29540.

5. 5 Chang, T. Y., Chang, C. C., Ohgami, N. and Yamauchi, Y. (2006) Cholesterol sensing, trafficking, and esterification. Annu. Rev. Cell Dev. Biol. 22; 129–157.

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