Notch Signaling May Be Involved in the Abnormal Differentiation of Epidermal Keratinocytes in Psoriasis

Author:

Ota Tami1,Takekoshi Susumu2,Takagi Tatsuya2,Kitatani Kanae2,Toriumi Kentaro2,Kojima Tomoko1,Kato Masayuki1,Ikoma Norihiro1,Mabuchi Tomotaka1,Ozawa Akira1

Affiliation:

1. Department of Dermatology, Tokai University School of Medicine

2. Department of Cell Biology, Division of Host Defense Mechanism, Tokai University School of Medicine

Publisher

Japan Society of Histochemistry & Cytochemistry

Subject

Cell Biology,Histology,Physiology,Biochemistry,Pathology and Forensic Medicine

Reference26 articles.

1. 1 Abdou, A. G., Maraee, A. H., Sharaf, A. and Elnaidany, N. F. (2012) Up-regulation of Notch-1 in psoriasis: an immuno­histochemical study. Ann. Diagn. Pathol. 16; 177–184.

2. 2 Bernerd, F., Magnaldo, T. and Darmon, M. (1992) Delayed onset of epidermal differentiation in psoriasis. J. Invest. Dermatol. 98; 902–910.

3. 3 Bhawan, J., Bansal, C., Whren, K. and Schwertschlag, U. (2004) K16 expression in uninvolved psoriatic skin: a possible marker of pre-clinical psoriasis. J. Cutan. Pathol. 31; 471–476.

4. 4 Blanpain, C., Lowry, W. E., Pasolli, H. A. and Fuchs, E. (2006) Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev. 20; 3022–3035.

5. 5 Del Amo, F. F., Smith, D. E., Swiatek, P. J., Gendron-Maguire, M., Greenspan, R. J., McMahon, A. P. and Gridley, T. (1992) Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development. Development 115; 737–744.

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