Amber therapy effect on the inflammatory process severity in purulent wounds in dogs

Abstract

Studying the amount of fibrinogen in the blood plasma of dogs is essential in determining the severity of the inflammatory process. In this regard, the aim of this work was to establish the level of fibrinogen in animals with the purulent-inflammatory process. The studies were performed by spectrophotometric method according to the generally accepted method. During the studies, the content of fibrinogen in the blood plasma of clinically healthy dogs was determined before medical care and during the wound process on the 3rd, 7th, 10th and 14th days of treatment. The results of the study on dogs with purulent skin wounds revel that the amount of fibrinogen before treatment was 2 times higher (p<0.001) compared with clinically healthy animals. On the 3rd day of the study, the content of fibrinogen in blood plasma in the animals of experimental group 1 and experimental group 2 was, respectively, 1.6 (p<0.001) and 1.5 (p<0.001) times higher than in the clinically healthy animals; the amount of fibrinogen was 1.7 times (p<0.001) higher in the control group of animals than in the clinically healthy dogs. On the 7th day of treatment, the level of fibrinogen in animals of the experimental group 1 was 1.2 times (p<0,01) higher than in clinically healthy dogs, while in the experimental group 2 its content was 1.1 times (p<0.05) higher. In contrast, it was 1.4 times (p<0.001) higher the control group dogs than in clinically healthy animals. Studies have shown that the administration of succinic acid and intravenous 1.5% solution of reamberin, a drug based on succinic acid, restores the level of fibrinogen in the plasma of dogs with purulent wounds on the 10th day of the wound process, compared with intravenous introduction of 5% glucose solution. The best therapeutic effect was obtained in the group of animals treated with 1.5% solution of reamberin