Folate supplementation as a strategy to reduce Neural Tube Defects

Author:

Jha ShreyaORCID,Kant ShashiORCID

Abstract

Folic acid is a vitamin known to prevent neural tube defects, megaloblastic anaemia, cardiovascular morbidity and mortality, etc. The main natural sources of folate are plant and vegetables e.g. green leafy vegetables, broccoli, asparagus, citrus fruits (orange, strawberry), beans, nuts, cauliflowers, beets, corn etc. and meat products like liver. The primary function of folate is its contribution in the synthesis and repair of the DNA. The bioavailability of food folate is approximately 50%. The bioavailability of folic acid taken with meal compared to with water on empty stomach is 85% and 100% respectively.(1) Hence, it is easier to achieve the recommended daily allowances with fortified food as compared to natural food due to higher stability and bioavailability of synthetic folate when compared to natural food.(2)

Publisher

Indian Association of Preventive and Social Medicine

Subject

Public Health, Environmental and Occupational Health

Reference33 articles.

1. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline [Internet]. Washington (DC): National Academies Press (US); 1998 [cited 2019 Jul 16]. (The National Academies Collection: Reports funded by National Institutes of Health). Available from: http://www.ncbi.nlm.nih.gov/books/NBK114310/

2. Sanderson P, McNulty H, Mastroiacovo P, McDowell IFW, Melse-Boonstra A, Finglas PM, et al. Folate bioavailability: UK Food Standards Agency workshop report. Br J Nutr. 2003;90(2):473–9.

3. Shane B. Folate status assessment history: implications for measurement of biomarkers in NHANES12345. Am J Clin Nutr. 2011;94(1):337S-342S.

4. Nutrient requirements for Indians – ICMR-NIN, 2020 [Internet]. Metabolic Health Digest. 2020 [cited 2022 June 18]. Available from: https://www.metabolichealthdigest.com/nutrient-requirements-for-indians-icmr-nin-2020/

5. Chanarin I, Macgibbon BM, O’sullivan WJ, Mollin DL. Folic-acid deficiency in pregnancy. The pathogenesis of megaloblastic anaemia of pregnancy. Lancet Lond Engl. 1959;2(7104):634–9.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3