EFFECT OF POLYMORPHISM OF THE GABRA2 GENE ON THE DEGREE OF RAT POISONING IN ACUTE ETHANOL INTOXICATION-Reference-Cited by-同舟云学术

EFFECT OF POLYMORPHISM OF THE GABRA2 GENE ON THE DEGREE OF RAT POISONING IN ACUTE ETHANOL INTOXICATION

Published:2019-06-28 Issue:3 Volume: Page:3-7
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Osechkina N. S.¹,Nazarov G. V.¹,Ivanov M. B.²,Batotsyrenova E. G.²,Kashuro V. A.²,Lapina N. V.²,Varlamova O. V.¹,Kravtsov I. S.¹,Babkin A. V.¹,Kraeva A. S.¹,Melekhova A. S.²,Voitsekhovich K. O.²,Lisitskii D. S.²

Affiliation:

1. Scientific Center «Signal»

2. Institute of Toxicology, Federal Medical Biological Agency

Abstract

Four polymorphic GABRA2 gene variations: rs105733011, rs8168342, rs198286814, rs198837638 that can influence the formation of different biological effects of the organism when exposed to ethanol have been investigated. For rs105733011 polymorphism the frequency of occurrence of the CT genotype was found to be significantly higher (p < 0,05) among animals with «severe intoxication» – 37,0% than with «mild intoxication» – 14,0%. For rs198286814 polymorphism the tendency to the most frequent occurrence of the AG genotype in the group of animals with «severe intoxication» was established. Significant differences in the distribution of occurrence frequencies of the GG/AG genotypes in the studied groups for polymorphic loci rs8168342 and rs198837638 were not revealed. It was concluded that the rs105733011 polymorphism can be one of the genetic markers allowing to predict the degree of inhibitory action of ethanol in acute alcohol intoxication.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

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