ACUTE TOXICITY OF CERIUM DIOXIDE NANOPARTICLES-Reference-Cited by-同舟云学术

ACUTE TOXICITY OF CERIUM DIOXIDE NANOPARTICLES

Published:2019-06-28 Issue:3 Volume: Page:56-62
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Khodykina N. V.¹,Tochilkina L. P.¹,Novikova O. N.¹,Sroslov M. S.¹,Pocheptsov A. Ya.¹,Velikorodnaya Yu. I.¹

Affiliation:

1. Research Institute for Hygiene, Toxicology and Occupational Pathology, Federal Medical and Biological Agency

Abstract

The resorptive effects of 0.01 M cerium nanodioxide sol upon single intraperitoneal administration to rats have been studied. The acute exposure to nanoparticles was found to have a dose-dependent general toxic effect on the body (weight loss, inflammatory changes in the abdominal organs, modification of individual behavior, hematological changes, metabolic imbalance), which develops on the background of POL activation. The prooxidant effect of cerium dioxide nanoparticles is demonstratively manifested at relatively high exposure levels (80–8 mg / kg). The threshold dose for the general toxic effect (Limch integr) is equal to 0.8 mg / kg.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

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