CHANGES IN THE CHEMICAL COMPOSITION OF BLOOD AND BRAIN OF RATS UNDER THE CONDITIONS OF MODELING OF THE MYELOABLATION REGIMEN OF CYCLOPHOSPHAMIDE ADMINISTRATION-Reference-Cited by-同舟云学术

CHANGES IN THE CHEMICAL COMPOSITION OF BLOOD AND BRAIN OF RATS UNDER THE CONDITIONS OF MODELING OF THE MYELOABLATION REGIMEN OF CYCLOPHOSPHAMIDE ADMINISTRATION

Published:2019-06-28 Issue:3 Volume: Page:13-18
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Ivnitsky Yu. Yu.¹,Schafer T. V.²,Tyaptin A. A.²,Rejniuk V. L.¹

Affiliation:

1. Institute of Toxicology, Federal Medical Biological Agency

2. State Scientific Research Test Institute of the Military Medicine, Ministry of Defense of the Russian Federation

Abstract

When modeling myeloablation cytostatic chemotherapy with cyclophosphamide in rats fulminant hyperammonemia was observed accompanied by an increase in the content of ammonia and glutamine, a decrease in the content of pyruvic and lactic acids in brain tissue. A positive correlation between the indicators of azotemia and the content of ammonia and glutamine in brain tissue was established. In loading test with ammonium acetate changes in the chemical composition of blood and brain tissue were more pronounced. The data obtained indicate the intensification of the intake of gastrointestinal ammonia into the brain from the blood, which leads to the depletion of the tissue pool of pyruvate with the introduction of cyclophosphane in doses used for myeloablation. Such changes create the conditions for disruption of energy supply of neurological functions during myeloablative cytotoxic chemotherapy using cyclophosphamide.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

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