MANIFESTATIONS OF SUBACUTE SYSTEMIC TOXICITY OF LEAD OXIDE NANOPARTICLES IN RATS AFTER AN INHALATION EXPOSURE-Reference-Cited by-同舟云学术

MANIFESTATIONS OF SUBACUTE SYSTEMIC TOXICITY OF LEAD OXIDE NANOPARTICLES IN RATS AFTER AN INHALATION EXPOSURE

Published:2021-01-05 Issue:6 Volume: Page:3-13
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Sutunkova M. Р.¹,Solovyeva S. N.¹,Chernyshov I. N.¹,Klinova S. V.¹,Gurvich V. B.¹,Shur V. Ya.²,Shishkina E. V.²,Zubarev I. V.²,Privalova L. I¹,Katsnelson B. A.¹

Affiliation:

1. Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers

2. Institute of Natural Sciences, Ural Federal University

Abstract

Outbred white female rats were exposed to an aerosol of lead oxide nanoparticles in a nose-only inhalation setup at an average concentration of 1.30 ± 0.10 mg / m3 during 5 days for 4 hours a day. In parallel, the control group of rats was subjected to sham exposure under similar conditions. The deposition of nanoparticles in the lungs and in the olfactory region of the brain was detected using transmission electron microscopy. Some disorders of the body state were detected in the exposed group, some of which can be considered as the result of a lead-specific toxic effect (an increase in the proportion of reticulocytes and in urinary excretion of δ-aminolevulinic acid), and others - the result of nanoparticles circumventing the blood-brain barrier (axon demyelination, vacuolization of the neurons’ cytoplasm).

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

Reference36 articles.

1. Katsnelson, B.A.; Privalova, L.I.; Sutunkova, M.P.; Minigalieva, I.A.; Gurvich, V.B.; Shur, V.Ya.; Shishkina, E.V.; Makeyev, O.H.; Valamina, I.E.; Varaksin, A.N.; et al. Experimental research into metallic and metal oxide nanoparticle toxicity in vivo. In Bioactivity of Engineered Nanoparticles; Yan, B., Zhou, H., Gardea-Torresdey, J., Eds.; Springer: Springer Nature Switzerland AG, 2017; Chapter 11, pp. 259–319.

2. Dumková, J.; Smutná, T.; Vrlíková, L.; Le Coustumer, P.; Večeřa, Z.; Dočekal, B.; Mikuška, P.; Čapka, L.; Fictum, P.; Hampl, A.; et al. Sub-chronic inhalation of lead oxide nanoparticles revealed their broad distribution and tissue-specific subcellular localization in target organs. Part. Fibre Toxicol. 2017, 14, 55.

3. Oberdörster, G.; Sharp, Z.; Atudore, V.; Elder, A.; Gelein, R.; Kreylin, W. Translocation of inhaled ultrafine particle to the brain. Inhal. Toxicol. 2004, 16, 437–445.

4. Elder, A.; Gelein, R.; Silva, V.; Feikert, T.; Opanashuk, L.; Carter, J.; Potter, R.; Maynard, A.; Ito, Y.; Finkelstein, J.; et al. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ. Health Perspect. 2006, 114, 1172–1178.

5. Kao, Y.-Y.; Cheng, T.-J.; Yang, D.-M.; Liu, P.-S. Demonstration of an olfactory bulb–brain translocation pathway for ZnO nanoparticles in rodent ells in vitro and in vivo. J. Mol. Neurosci. 2012, 48, 464–471.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Comparative Analysis of Own Experimental Data on Changes in Rat Behavioral Responses Following Subchronic Exposure to Various Nanoparticles;ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT;2023-09