PECULIARITIES OF METABOLIC CHANGES IN EXPERIMENTAL ANIMALS AT EARLY TERMS OF PHARMACOLOGICAL CORRECTION OF TOXIC LIVER DISEASES-Reference-Cited by-同舟云学术

PECULIARITIES OF METABOLIC CHANGES IN EXPERIMENTAL ANIMALS AT EARLY TERMS OF PHARMACOLOGICAL CORRECTION OF TOXIC LIVER DISEASES

Published:2020-02-24 Issue:1 Volume: Page:13-19
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Timasheva G. V.¹,Repina E. F.¹,Karimov D. O.¹,Khusnutdinova N. Yu.¹,Mukhammadieva G. F.¹,Bakirov A. B.¹,Smolyankin D. A.¹,Baigildin S. S.¹

Affiliation:

1. Ufa Institute of Occupational Health and Human Ecology

Abstract

The paper presents the results of studies on metabolic changes in experimental animals with acute tetrachloromethane poisoning and further damage correction using substances possessing hepatoprotective properties: oxymethyluracil, ademethionine and ethylmethylhydroxypyridine succinate. It has been revealed that oxymethyluracil exhibits heteroprotective properties at the earliest stages of acute toxic liver damage with chemical toxicants: it has membrane-stabilizing properties, normalizes the levels of antioxidant system parameters, thereby restoring the oxidative-antioxidant balance in hepatocytes. Oxymethyluracil has more pronounced hepatoprotective properties at the early stages of treatment in comparison with ademethionine and ethylmethylhydroxypyridine succinate. The results obtained are important in terms of the prospective use of oxymethyluracil for the relief of hepatotoxic effects in acute exposure to hepatropic chemicals under environmental and industrial poisoning.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

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