USE OF CLUSTER ANALYSIS FOR EVALUATION OF ACUTE POISONING REHABILITATION TREATMENT EFFICIENCY

Abstract

Observations of 153 patients admitted to the toxicological department of the N.V. Sklifosovsky Research Institute for Emergency Medicine after severe poisoning with psychopharmacological agents (36), cauterizing fluids (67) and neurotoxicants (drugs of the opium group, ethanol and psychopharmacological agents) (50) were summarized. A hierarchical cluster analysis was used to assess the systemic response of the body to a chemical injury of varying severity and the treatment used. The data obtained shows that taking into account the complexity of the response of homeostasis indicators to various impacts the characteristics of the shifts to the manifestations of mentioned acute poisonings and treatment measures in the rehabilitation period with the use of cluster analysis should be evaluated using data that indicates changes in the strength of the bonds (proximity levels) both for individual indicators and for the values of intrasystemic connections in individual systems and between them. Cluster analysis provides an opportunity to obtain new information about the pathogenesis of the studied poisonings and also has predictive capabilities. Changes in the assessed indicators obtained by cluster analysis correspond to their shifts in the process of one dimensional analysis, positive results of treatment (reduction of treatment duration) and, therefore, are recommended for practical use.