PARTICULARITIES OF THE IMMUNE RESPONSE IN PERSONS PROFESSIONNALLY EXPOSED TO BERYLLIUM

Author:

Stosman K. I.1,Lukovnikova L. V.1

Affiliation:

1. «Institute of Toxicology» of Federal Medico-Biological Agency

Abstract

An examination was performed of 50 employees at an enterprise where they were in professional contact with beryllium. In most workers, it was detected an increase of interleukine-8, interferon- , growing level of immunoglobulin E and circulating immune complexes. It was shown that the contact with beryllium compounds leads to the interferon- level growth only in women. In men, alterations are identified in the direction of increased concentrations of common immunoglobulin E and circulating immune complexes.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

Reference20 articles.

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2. Zabrodskii P. F., Mandych V. G. Immunotoksikologiya ksenobiotikov: Monografiya. SVIBKhB; 2007.

3. Toxicological profile for beryllium. U.S. Department of health and human services Public Health Service Agency for Toxic Substances and Disease Registry. 2002; 247.

4. Reinhild Klein, Michael Schwenk, Douglas M. Templeton. Cytokine profiles in human exposure to metals. Pure Appl. Chem. 2006; 78 (11): 2155–68.

5. Maier L.A., Sawyer R.T., Tinkle L.A. IL-4 fails to regulate in vitro berylliuminduced cytokines in berylliosis. Eur Respir J. 2001; 17: 403–

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