ACUTE TOXICITY OF A NEW BENZIMIDAZOLE DERIVATIVE WITH ANTITHROMBOGENIC PROPERTIES-Reference-Cited by-同舟云学术

ACUTE TOXICITY OF A NEW BENZIMIDAZOLE DERIVATIVE WITH ANTITHROMBOGENIC PROPERTIES

Published:2021-03-08 Issue:1 Volume:1 Page:52-57
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Spasov A. A.¹,Kucheryavenko A. F.²,Maltsev D. V.³,Miroshnikov М. V.²,Sirotenko V. S.²,Sultanova К. Т.²,Gaidukova К. A.²,Skripka М. О.²

Affiliation:

1. Volgograd State Medical University, Department of Pharmacology and Bioinformatics, RF Ministry of Health; Volgograd Medical Research Center, Laboratory of Experimental Pharmacology

2. Volgograd State Medical University, Department of Pharmacology and Bioinformatics, RF Ministry of Health

3. Volgograd State Medical University, Department of Pharmacology and Bioinformatics, RF Ministry of Health;Volgograd Medical Research Center, Laboratory of Experimental Pharmacology

Abstract

The paper presents the results of studying the toxicological profile of a new pharmaceutical substance RU891 with antithrombogenic properties. The minimum toxic dose (TDmin) for RU-891 by peroral administration is 230 mg/kg < TDmin ≤ 460 mg/kg. In experiments on the acute toxicity of the compound RU-891, the nature and severity of its damaging effect on the body of experimental animals were established and the safety of its action was evaluated. When studying the toxic effect of the test sample, the tolerated and toxic doses of RU-891 were determined, and the most sensitive organs and systems of the body were identified.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

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