RELATIONSHIP BETWEEN METABOLIC AND IMMUNOLOGICAL INDICATORS AFTER CORRECTION BY ALLOGENIC HEPATOCYTES IN ACUTE TOXIC, ISCHEMIC AND ALCOHOL LIVER INJURY-Reference-Cited by-同舟云学术

RELATIONSHIP BETWEEN METABOLIC AND IMMUNOLOGICAL INDICATORS AFTER CORRECTION BY ALLOGENIC HEPATOCYTES IN ACUTE TOXIC, ISCHEMIC AND ALCOHOL LIVER INJURY

Published:2021-03-08 Issue:1 Volume:1 Page:27-37
ISSN:0869-7922
Container-title:Toxicological Review
language:
Short-container-title:Toksikologičeskij vestnik

Author:

Litvinova Е. S.¹,Konoplya A. I.¹,Kholimenko I. M.²,Kotsar’ A. G.²

Affiliation:

1. Kursk State Medical University

2. Kursk City Clinical Hospital for Emergency Medicine

Abstract

Immune disorders arising from liver damage of various origins and the mechanisms of their development are still poorly understood. The functions of the immune system are carried out against the background of metabolic processes and their shifts caused by the action of various agents on the body, as well as liver cells - hepatocytes. Typical metabolic changes that occur when the liver is affected by various toxic factors are combined with certain features of metabolic disorders in certain organs and tissues, due to the specifics of their structural and functional organization, the nature of the inducing agent and the primary link of its effect on cells and the body as a whole. The relationship of numerous metabolic changes, violations of the functional activity of hepatocytes arising in such a pathology with the dysfunction of the immune system has not yet been sufficiently studied, as well as the most effective methods of correction have not been established. Currently, the issues of pathogenesis, diagnosis and treatment of acute liver diseases remain among the most relevant in medicine, both due to the complexity of diagnosis and the choice of optimal treatment methods, and the tendency towards an increase in the number of patients with these diseases. The emergence and development of cellular technologies have created serious scientific prerequisites in this area.

Publisher

Russian Register of Potentially Hazardous Chemical and Biological Substances

Reference15 articles.

1. Medvedeva S.Yu., Mukhlynina E.A., Bulavintseva T.S., Danilova I.G. Stem cell factor participation in the reparative regeneration of the liver during its toxic damage. Medical Immunology. 2015; 17: 32 (in Russian).

2. Zheksenova A.N., Nasyrov I.N., Kaldybaeva A.T., Batyrova T.Zh., Almakhanova M.Zh. Morphological changes in the lymph nodes in rats under the inﬂammatory process against the background of exposure to fetal hepatocytes. Allergology and Immunology. 2015; 16(3): 311 (in Russian).

3. Lyzikov A.N., Skuratov A.G., Osipov B.B. Mechanisms of liver regeneration in normal and pathological conditions. Problems of Health and Ecology. 2015; 1 (43): 4-9 (in Russian).

4. Ljundup A.V., Onishchenko N.A., Shagidulin M.Yu., Krashennikov M.E. Liver and bone marrow stem progenitor cells as regulators of regenerative regeneration of damaged liver. Bulletin of Transplantology and Artiﬁcial Organs. 2010; 12(2):100- 107 (in Russian).

5. Liu K.X., Kato Y., Matsumoto K., Nakamura T., Kaku-T., Sugiyama Y. Characterization of the enhancing eﬀect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes. Pharm Res. 2009; 26(4):1012-1021.