Author:
Sadiq, F. U. ,Abalaka, M.E ,Babayi, H.
Abstract
This study investigates the toxicological profile of Securidaca longipedunculatain rats. Sub- acute toxicity study was conducted by oral administration of the extracts to rats at daily doses of 25, 50 and 100mg/kg body weight for 28 days. Methanol leaf extract of S. longipedunculata caused significant (p< 0.05) increase in serum urea, creatinine, sodium & proteins but significantly (p< 0.05) decreased the serum alkaline phosphatase (ALP) and cholesterol concentration when compared with the controls. However, there was no significant (p> 0.05) difference in serum aspartate transaminase (AST), alanine transaminase (ALT), potassium, triglyceride albumin and bilirubin concentration when compared with control. Jobelyn and dexamethazone caused significant (p< 0.05) increase in serum AST, urea, triglycerides, sodium and protein. Dexamethazone caused significant increase (p<0.05) in bilirubin, cholesterol, and a decrease in serum ALP and creatinine concentration when compared with the control. The extract also had no significant (p>0.05) effect on hematological parameters except for a significant increase (p<0.05) in white blood cells when compared with the normal control. The plant extracts have shown no serious adverse effect on hematological and biochemical parameters. Thus, S. longipedunculata methanol leaf extract could be considered as a natural source of antibiotics for therapeutic purposes.
Publisher
Umaru Musa YarAdua University Katsina NG
Reference48 articles.
1. Abalaka, M. E., Olonitola, O. S., Onaolapo, J. A., &Inabo, H. I. (2009). Evaluation of acute toxicity of Momordicacharantia extract, using wistar rats to determine safety level and usefulness of the plant ethnochemotheraphy. Int J Appl Sci, 3, 1-6.
2. Abalaka, M.E., Adeyemo, S.O., &Daniyan, S.Y. (2011). Evaluation of the antimicrobial potentials of leaves extracts of Khaya senegalensis. Journal of Pharmaceutical Research & Opinion, 1(2), 48 - 51.
3. https://doi.org/10.5923/j.microbiology.20120202.01
4. Agbaje, E. O., & Adekoya, M. E. (2012). Toxicological profile of aqueous Root extract of SecuridacalongepeduculataFresen (Polygalaceae) after 90-day Treatment in Rats. International Journal of Toxicological and Pharmacological Research, 4(1), 5-11.
5. Akanji, M. A., Salau, A. K., & Yakubu, M. T. (2013). Safety evaluation of aqueous extract of Cratevaadansonii leaves on selected tissues of rats. Fount J Nat Appl Sci, 2(1), 17-28.