Effects of nafamostat mesilate on 5-hydroxytryptamine release from isolated ileal tissues induced by anti-cancer drugs in rats

Author:

KIKUCHI Kaoru1,HAMAUE Naoya1,MACHIDA Takuji1,IIZUKA Kenji1,MINAMI Masaru1,HIRAFUJI Masahiko1

Affiliation:

1. Department of Pharmacological Sciences, School of Pharmaceutical Sciences, Health Sciences University of Hokkaido

Publisher

Biomedical Research Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference19 articles.

1. Aoyama T, Ino Y, Ozeki M, Oda M, Sato T, et al. (1984) Pharmacological studies of FUT-175, nafamostat mesilate. I. Inhibition of protease activity in in vitro and in vivo experiments. Jpn J Pharmacol 35, 203–227.

2. Cho EY, Choi SC, Lee SH, Ahn JY, Im LR, et al. (2011) Nafamostat mesilate attenuates colonic inflammation and mast cell infiltration in the experimental colitis. Int Immunopharmacol 11, 412–417.

3. Dugina TN, Kiseleva EV, Glusa E and Strukova SM (2003) Activation of mast cells induced by agonists of protease-activated receptors under normal conditions and during acute inflammation in rats. Eur J Pharmacol 471, 141–147.

4. Hesketh PJ (2008) Chemotherapy-induced nausea and vomiting. N Engl J Med 358, 2482–2494.

5. Hirafuji M, Minami M, Endo T, Ogawa T, Kato K, et al. (2000) Intracellular regulatory mechanisms of 5-HT release from enterochromaffin cells in intestinal mucosa. Biog Amines 16, 29–52.

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