Acrolein, a highly toxic aldehyde generated under oxidative stress in vivo, aggravates the mouse liver damage after acetaminophen overdose
Author:
Affiliation:
1. Research Institute for Biomedical Sciences, Tokyo University of Science
2. Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science
Publisher
Biomedical Research Press
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference22 articles.
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3. 3 Daimon M, Sugiyama K, Kameda W, Saitoh T, Oizumi T, Hirata A, Yamaguchi H, Ohnuma H, Igarashi M and Kato T (2003) Increased urinary levels of pentosidine, pyrraline and acrolein adduct in type 2 diabetes. Endocr J 50, 61–67.
4. 4 Hamann K, Durkes A, Ouyang H, Uchida K, Pond A and Shi R (2008) Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. J Neurochem 107, 712–721.
5. 5 Ishida Y, Kondo T, Kimura A, Tsuneyama K, Takayasu T and Mukaida N (2006) Opposite roles of neutrophils and macrophages in the pathogenesis of acetaminophen-induced acute liver injury. Eur J Immunol 36, 1028–1038.
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