Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat
Author:
Publisher
Biomedical Research Press
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference19 articles.
1. Maturational arrest from CD4+8+ to CD4+8- thymocytes in a mutant strain (LEC) of rat.
2. Bone marrow-derived progenitor T cells convey the origin of maturational arrest from CD4+CD8+ to CD4−CD8+ thymocytes in LEC mutant rats
3. A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat
4. Protein–tyrosine phosphatase-kappa regulates CD4+ T cell development through ERK1/2-mediated signaling
5. Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling
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