Author:
Alpizar-Ramos Socorro,Parra Mario González-de la
Abstract
A strategy based on sequential design of experiments (screening, optimization and confirmation) was used to develop a tablet formulation of ibuprofen (400 mg) that is manufactured by direct compression. This formulation has a high content of ibuprofen (76%), in spite of the poor flowability of the drug substance. Sequential design of experiments proved to be an effective and efficient strategy in formulation development.
Publisher
Open Science Publishers LLP
Cited by
2 articles.
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