Effect of Fenvalerate Toxicity on Biochemical and Haematological Parameters and Ameliorative Effect of Quinoa Seeds in Swiss Albino Mice

Abstract

Fenvalerate is a synthetic pyrethroid insecticide with moderate mammalian toxicity. It affects the central nervous system and is used for the control of flies and ticks in barns and stables. Exposure of this insecticide to humans occurs in the field. The present study was conducted to observe the toxicity of insecticide on biochemical and blood parameters after treatment with fenvalerate, a synthetic pyrethroid and find out the possible protective role of Quinoa seeds in Swiss albino mice. The mice in this study were divided into 5 groups, and 6 animals were taken into each group. Group A control mice received vehicle distilled water only. Group B and C were administered with fenvalerate at 12.5 and 25 mg/kg body weight respectively for 30 days. Group D was administered 12.5 mg/kg fenvalerate +25 mg/kg Quinoa seeds and Group E received 25 mg/kg fenvalerate +50 mg/kg Quinoa seeds. Fenvalerate treatment resulted in a significant increase in the levels of alkaline phosphatase, acid phosphatase, Serum Glutamate Pyruvate Transaminase (SGPT) and Serum Glutamate Oxaloacetate Transaminase (SGOT). Administration of Quinoa seeds along with fenvalerate resulted in a decrease in these biochemical values. A significant increase in the number of RBC, WBC and haemoglobin was observed in the fenvalerate-treated groups. The result suggests a possible protective role of Quinoa seeds on fenvalerate toxicity.